Prolonged ozone exposure in an allergic airway disease model: Adaptation of airway responsiveness and airway remodeling
نویسندگان
چکیده
منابع مشابه
Prolonged ozone exposure in an allergic airway disease model: Adaptation of airway responsiveness and airway remodeling
BACKGROUND Short-term exposure to high concentrations of ozone has been shown to increase airway hyper-responsiveness (AHR). Because the changes in AHR and airway inflammation and structure after chronic ozone exposure need to be determined, the goal of this study was to investigate these effects in a murine model of allergic airway disease. METHODS We exposed BALB/c mice to 2 ppm ozone for 4...
متن کاملEffect of P2X4R on airway inflammation and airway remodeling in allergic airway challenge in mice.
P2X4 receptor (P2X4R) is the most widely expressed subtype of the P2XRs in the purinergic receptor family. Adenosine triphosphate (ATP), a ligand for this receptor, has been implicated in the pathogenesis of asthma. ATP‑P2X4R signaling is involved in pulmonary vascular remodeling, and in the proliferation and differentiation of airway and alveolar epithelial cell lines. However, the role of P2X...
متن کاملEstablishing an Airway
لوله گذاری داخل تراشه برای بیمارانی که تحت بیهوشی عمومی قرار می گیرند از کارهای معمولی و مطمئن است که باید انجام گردد. بدیهی است شخص انجام دهنده باید اطلاعات و آگاهی کافی از وضع آناتومی راههای هوایی فوقانی، تجهیزات و داروها بخصوص شل کننده های عضلانی داشته باشد.
متن کاملAirway responsiveness in CD38-deficient mice in allergic airway disease: studies with bone marrow chimeras.
CD38 is a cell-surface protein involved in calcium signaling and contractility of airway smooth muscle. It has a role in normal airway responsiveness and in airway hyperresponsiveness (AHR) developed following airway exposure to IL-13 and TNF-α but appears not to be critical to airway inflammation in response to the cytokines. CD38 is also involved in T cell-mediated immune response to protein ...
متن کاملAllergic Fungal Airway Disease.
Fungi are ubiquitous and form their own kingdom. Up to 80 genera of fungi have been linked to type I allergic disease, and yet, commercial reagents to test for sensitization are available for relatively few species. In terms of asthma, it is important to distinguish between species unable to grow at body temperature and those that can (thermotolerant) and thereby have the potential to colonize ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Respiratory Research
سال: 2006
ISSN: 1465-993X
DOI: 10.1186/1465-9921-7-24